120 Microneedle array delivery of skin targeted adenovector vaccines
نویسندگان
چکیده
منابع مشابه
Transdermal Delivery of siRNA through Microneedle Array
Successful development of siRNA therapies has significant potential for the treatment of skin conditions (alopecia, allergic skin diseases, hyperpigmentation, psoriasis, skin cancer, pachyonychia congenital) caused by aberrant gene expression. Although hypodermic needles can be used to effectively deliver siRNA through the stratum corneum, the major challenge is that this approach is painful an...
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SUMMARY We introduce the Nanopatch – a practical needle-free device that targets a narrow layer just below the skin surface rich in antigen presenting cells for improved vaccination over the needle and syringe (which instead primarily targets the muscle). Case studies of vaccination are presented, including Nanopatch delivery of influenza vaccines inducing immune responses comparable to needle ...
متن کاملGene Silencing in Skin After Deposition of Self-Delivery siRNA With a Motorized Microneedle Array Device
Despite the development of potent siRNAs that effectively target genes responsible for skin disorders, translation to the clinic has been hampered by inefficient delivery through the stratum corneum barrier and into the live cells of the epidermis. Although hypodermic needles can be used to transport siRNA through the stratum corneum, this approach is limited by pain caused by the injection and...
متن کاملToward Self‐Powered Wearable Adhesive Skin Patch with Bendable Microneedle Array for Transdermal Drug Delivery
A wearable adhesive skin patch for transdermal drug delivery is developed with bendable microneedles, dry adhesive and triboelectric energy harvester (TEH). The bendable microneedle array can overcome the needle breakage issue. The dry adhesive can realize a conformal attachment. The TEH can generate power when attached on flat skin or joint to power active components to be integrated in the fu...
متن کاملEffect of microneedle geometry and supporting substrate on microneedle array penetration into skin.
Microneedles are being fast recognized as a useful alternative to injections in delivering drugs, vaccines, and cosmetics transdermally. Owing to skin's inherent elastic properties, microneedles require an optimal geometry for skin penetration. In vitro studies, using rat skin to characterize microneedle penetration in vivo, require substrates with suitable mechanical properties to mimic human ...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2018
ISSN: 0022-202X
DOI: 10.1016/j.jid.2018.03.124